At low concentrations, CO could favorably modulate inflammation, apoptosis, and cell proliferation, in addition to regulating mitochondrial biogenesis.

In physiological amounts endogenous carbon monoxide functions as a neurotransmitter.

The human body continually produces small amounts of CO, as one of the end products of the catabolism of hemoglobin and other heme groups. The repercussions that these phenomena have on the material losses and particularly on human lives are evident, conditioning sequels in the survivors.īiochemical suffocants are substances that cause oxygen deficiency without interfering with the mechanics of respiration, either by displacing oxygen from the air (simple suffocants) or by altering biological oxidative mechanisms (chemical suffocants) 1. In children, the first place was due to inhalation of toxic gases (41.8%), followed by the intake of medications (18.3%), and exposure to pesticides (13.1%) 7. In adults, mortality due to accidental poisoning occurred: in the first place due to the intake of medications (21.6%), inhalation of toxic gases (20.4%) ranked second, and exposure to pesticides (13.9%) third. 72% of cases are accidental and 28% correspond to suicide. In Mexico, they are the cause of around 13,600 hospital discharges that originate 34,900 days of hospital stay 5, As a consequence, 1,400 people die, 87% adults and 13% children 6. Every year many people die as a result of poisoning, most of them being preventable and avoidable. Poisoning is considered a growing public health problem in most countries. In a high percentage of poisoned patients, basic support accompanied by adequate fluid, electrolyte, and acid-base resuscitation is usually sufficient for stabilization 3, 4. A toxic substance is a substance of a chemical nature that, depending on the concentration it reaches in the organism, and the time in which this happens, acts on biological systems causing morphological, functional, or biochemical alterations 1 Generally, brings with it harmful effects that can range from mild to fatal, which is why they have come to be considered by some as “multiple traumas of chemical origin” 2.

Lilly cyanide antidote kit